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Serendipity in Modern Medical Breakthroughs
by Morton Meyers M.D.
The Normal versus the Revolutionary
In his highly influential 1962 book The Structure of Scientific Revolutions,
Thomas Kuhn contributed an idea that changed how we see the
history of science.6 Kuhn makes a distinction between normal and
revolutionary science. In normal science, investigators work within
current paradigms and apply accumulated knowledge to clearly defined
problems. Guided by conventional wisdom, they tackle problems
within the boundaries of the established framework of beliefs
and approaches. They attempt to fit things into a pattern. This approach
occupies virtually all working researchers. Such efforts, according
to Nobel laureate Howard Florey, add small points to what
will eventually become a splendid picture much in the same way that
the Pointillistes built up their extremely beautiful canvasses.
Kuhn portrays such scientists as intolerant of dissenters and preoccupied
with what he dismissively refers to as puzzle-solving. Nonetheless,
a period of normal science is an essential phase of scientific
progress. However, it is revolutionary science that brings creative
leaps. Minds break with the conventional to see the world anew. How
is this accomplished? The surprising answer may be blindly! Systematic
research and happenstance are not mutually exclusive; rather
they complement each other. Each leads nowhere without the other.
According to this view, chance is to scientific discovery as blind
genetic mutation and natural selection are to biological evolution. The
appearance of a variation is due not to some insight or foresight but
rather to happenstance. In groping blindly for the truth, scientists
sometimes accidentally stumble upon an understanding that is ultimately
selected to survive in preference to an older, poorer one.
As explained by Israeli philosophers of science Aharon Kantorovich
and Yuval Neeman, Blind discovery is a necessary condition
for the scientific revolution; since the scientist is in general imprisoned
within the prevailing paradigm or world picture, he would not
intentionally try to go beyond the boundaries of what is considered
true or plausible. And even if he is aware of the limitations of the scientific
world picture and desires to transcend it, he does not have a
clue how to do it.
Excerpted from Happy Accidents by Morton Meyers, M.D. Copyright © 2007 by Morton Meyers, M.D. Excerpted by permission of Arcade Publishing. All rights reserved. No part of this excerpt may be reproduced or reprinted without permission in writing from the publisher.
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